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Monday, June 14, 2021

How bad is the COVID-19 variant problem? We won’t know until we test for it

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The Times Editorial Board, Los Angeles Times, (TNS)

As COVID-19 vaccinations slowly become available to more Americans, variants of the novel coronavirus have started circulating in the United States and elsewhere, making people wonder whether the shots are still worth getting.

The answer to that is yes, more so than ever.

The more freely the virus circulates, the more opportunity it has to mutate, scientists say. The best thing we can do to contain the number of variants is to vaccinate the world, as fully and as quickly as possible, while continuing to limit infections with face coverings and social distancing.

So far, the variants — the three main ones were first found in the United Kingdom, South Africa and Brazil — appear to be more contagious than the original version. Early tests have indicated that the U.K. strain might be more lethal as well.

Existing vaccines appear to be at least somewhat effective against these variants, but it’s still unclear just how effective. And new variants are almost certain to arrive. Creating new vaccines or booster shots to counter these changes are two options. And one of the most tantalizing possibilities that science offers at this point is a pan-coronavirus vaccine that would target parts of the virus that don’t mutate rapidly (researchers at UCI Health are among those working on this). That wouldn’t just protect against all forms of COVID-19, but against future pandemics involving coronaviruses. For that matter, it also would prevent common colds caused by coronavirus. And it would allow science to avoid a game of Whac-A-Mole with a dangerous and ever-changing threat.

But in the short term, before U.S. health experts can tackle the problem of a mutating virus effectively, they need a much better picture of what’s out there already. The nation has done a dismayingly lackluster job sequencing the genomes of the virus samples collected from around the country, which would identify variations in the virus, even though laboratories have been waiting for samples to test. According to Science magazine, this country is sequencing fewer than four samples out of 10,000, compared with Denmark, which has sequenced more than half of positive samples.

An administration official told CNN that sequencing efforts are ramping up, but “we are not where we want to be.” You think?

All three of the major variants have now been found in the United States, but it’s important to know which variants are circulating where. That’s how scientists learn how well-existing vaccines protect against them, and it allows public health officials to target lockdowns at the hot spots where more dangerous versions are circulating. Up to now, the Biden administration’s priority has rightly been on ramping up vaccine production and distribution, but it cannot waste any more time getting the nation up to speed on sequencing.

This is how important genomic sequencing is: No one really knows if the U.K. variant actually originated there. It was discovered there because the country has a robust and coordinated genomic sequencing operation. There could be other variants, originating in this country, that have not been identified because we simply haven’t been looking for them.

Using the mRNA technology employed for the Pfizer and Moderna vaccines, which enables vaccines to be developed much faster than traditional methods do, pharmaceutical executives say they could retool existing vaccines to handle one or more variants within six to eight weeks. But that is not a good reason to wait for vaccination. It could be months before new vaccines are available — and no one knows which new variants might be circulating then. Meanwhile, the current mRNA vaccines appear to have at least partial effectiveness against the new strains, preventing mild cases and, like the flu vaccine, easing the effects of serious ones.

The more we vaccinate — and wear masks, keep our distance from others and practice the remaining disease-prevention techniques that have become all too familiar — the more we keep the virus from spreading. The less it spreads, the less opportunity it has to change. But protecting people from new versions of the virus first means knowing what and where those versions are, through a federally coordinated program of genomic sequencing. That should become the next big anti-COVID-19 effort of the Biden administration.

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(c)2021 the Los Angeles Times
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